Glossary term
First-pass metabolism: First-pass metabolism is the breakdown that happens when a medicine taken by mouth passes through the gut and liver before reaching the bloodstream.
Why this term matters
It helps explain why oral products may feel slower, sometimes less predictable, and may interact with liver metabolism.
UK medical cannabis context
Useful on more advanced oral-oil explainer pages.
What not to assume
It is a pharmacology concept, not a shorthand for whether a medicine is “strong”.
Careful wording: Avoid turning a complex pharmacology term into dosing advice.
Related glossary terms
Related MCPH pages
Sources and review notes
This entry is educational vocabulary, not medical advice. Suitability, prescribing, product choice and monitoring belong with a qualified clinician or pharmacist.
- Technical chemistry / terminology review note. Used as terminology context only, not as standalone clinical guidance.
- NHS medical cannabis guidance
- NICE NG144: cannabis-based medicinal products