Glossary term

Dependence: Dependence means the body or mind becomes used to a medicine in a way that can make stopping difficult or lead to withdrawal symptoms. It is not identical to addiction, but the distinction matters clinically.

EssentialSafetySource quality: HighLast updated: 29 June 2026

Why this term matters

Patients need this term because NICE specifically tells prescribers to discuss dependence risk.

UK medical cannabis context

NICE notes the potential for dependence, diversion and misuse, especially with THC.

What not to assume

Dependence risk may differ by product, THC exposure, dose and duration.

Careful wording: Avoid telling readers dependence is impossible under medical supervision.

Related glossary terms

Related MCPH pages

Sources and review notes

This entry is educational vocabulary, not medical advice. Suitability, prescribing, product choice and monitoring belong with a qualified clinician or pharmacist.