Limonene

Limonene can be reported as d-limonene

Limonene is a monoterpene name, while d-limonene identifies one form used in the study material. Keep that distinction visible when comparing a product report with a paper. A citrus association may explain why the name appears in plant or fragrance contexts, but it does not supply a patient outcome.

The human trial tested a combination supplement

A double-blind randomised placebo-controlled trial studied a food supplement containing standardised menthol, limonene and gingerol in people with irritable bowel syndrome or functional dyspepsia. Any result belongs to that multi-ingredient supplement and its participants. The design cannot separate a limonene-only effect, and it did not test medical cannabis.

A secondary Marijuana Grower’s Handbook reference for limonene helps with terminology and provenance, but it is not clinical evidence.

A limonene line is still only one part of a composition record

When limonene appears on a certificate of analysis, the relevant context includes the form reported, amount, batch and the other constituents. The human combination trial does not make a limonene-containing cannabis product equivalent to the supplement. The terpene reference is useful for checking the name; it cannot turn the name into a product recommendation.

Related conditions

• Anxiety disorders
• Depression
• Migraine and headache

Sources

• Menthol, limonene and gingerol food-supplement trial (primary human randomised placebo-controlled combination study, PMID 35704960, DOI 10.1371/journal.pone.0263880).